Guanidine-Annellated Heterocycles: Design, Synthesis and Biological Evaluation of Novel 2-Aminopyridoimidazotriazines, Pyridoimidazopyrimidines, Pyridoimidazotriazoles and Pyridoimidazoles
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چکیده
Starting from 2,3-diaminopyridine, several novel 2-amino [2,3:4,5] imidazo [1,2-a] [1,3,5] triazines (2-6), 2(1H-imidazo [4,5-b] pyridine-2-yl) imino) -2,3-dihydro-1H-imidazoles (7-11), pyrido [2,3,4,5] imidazo [1,2-a] pyrimidones (13-16), 9H [1,2,4] triazolo [4,3:1,2] imidazo [4,5-b] pyridines (20-21) and 1-(1H-imidazo [4,5-b] pyridine-2-yl) -3-methyl-1H-pyrazol-5-ol (22a) were synthesized in a very good yield. Compound 2-6, 7-11, 13-16, 20 and 21 were screened in vitro for their antibacterial and antifungal activity by the agar diffusion method and most of them showed a pronounced anti-inhibitory effect. Compound 22a showed pronounced analgesic activity by i.p. injection of 0.5-1.0 mg/kg in conscious rats in a hot plate testing procedure.
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